Polyclonal Antibody to HOIL-1L/RBCK1
Fig-1: Western blot analysis of HOIL-1L/RBCK. Anti-HOIL-1L/RBCK antibody (11-6007) was used at 2 µg/ml on (1) A375, (2) 293 and (3) Jurkat lysates.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein A Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
RBCK1 (RanBP-type and C3HC4-type zinc finger containing 1) is a transcription factor belonging to the RING-IBR protein family. It shuttles between the nucleus and cytoplasm, possessing both the nuclear export and localization signals within its amino acid sequence. RBCK1 deficiency causes polyglucosan storage myopathy associated with progressive muscle weakness and cardiomyopathy. RBCK1 negatively regulates the cellular antiviral response. RBCK1 regulates cell cycle progression and proliferation of ERalpha (estrogen receptor alpha)-positive breast cancer cells by supporting transcription of ERalpha and cyclin B1.
Western blot analysis: 2-4 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Post transnational modification: | Phosphorylated. In vitro, phosphorylation inhibits auto-ubiquitination activity (By similarity). |
| BioGrid: | 115862. 88 interactions. |
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