Polyclonal Antibody to Histone H2A
Fig-1: Western blot analysis of Histone H2A. Anti- Histone H2A antibody (11-7017) was used at 2 µg/ml on Brain lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein A Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Histone H2A is one of the five main histone proteins that is approximately 14 kDa protein consisting of 130 amino acid residues and present in the nucleosome in the form of H2A-H2B heterodimer. H2A is mainly composed of non-allelic variants and interestingly atypical variants, such as, MacroH2As, H2A.X, H2A-Bbd, differ considerably in size with H2A. H2A undergoes various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination, which occur in response to various stimuli and directly affect the accessibility of chromatin to transcription factors. This gene is mainly expressed on blood, brain, breast and it plays a significant role in the disease, riddle syndrome.
Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis: 5 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
Susanne Hellmuth,Olaf Stemmann
In vitro reconstitution reveals requirement of Nek2a and cyclin A2 for Wapldependent removal of cohesin from prophase chromatin
bioRxiv preprint doi: https://doi.org/10.1101/2024.03.12.584565; this version posted March 12, 2024
| Subcellular location: | Nucleus, Chromosome |
| Post transnational modification: | Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. |
| BioGrid: | 113931. 50 interactions. |
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