Polyclonal Antibody to GSK3beta (Phospho-Ser9)

Figure 1: Western blot analysis of extracts from 293 cells untreated(lane 1) or treated with serum(lane 2) using GSK3ÃƒŸ(Phospho-Ser9) Antibody 35-1001.

Polyclonal Antibody to GSK3beta (Phospho-Ser9)

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Figure 1: Western blot analysis of extracts from 293 cells untreated(lane 1) or treated with serum(lane 2) using GSK3ÃƒŸ(Phospho-Ser9) Antibody 35-1001.

Figure 2: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using GSK3ÃƒŸ (Phospho-Ser9) Antibody 35-1001 (left) or the same antibody preincubated with blocking peptide (right).

Figure 3: Immunofluorescence staining of methanol-fixed Hela cells showing cytoplasmic staining using GSK3ÃƒŸ(Phospho-Ser9) Antibody 35-1001.

Figure 4: Immunohistochemical analysis of paraffin-embedded human Lung carcinoma tissue using GSK3ÃƒŸ (Phospho-Ser9) Antibody 35-1001.

Figure 5 : Immunofluorescence staining of methanol-fixed Hela cells showing cytoplasmic staining using GSK3ÃƒŸ (Phospho-Ser9) Antibody 35-1001.

Figure 6 : Western blot analysis of extracts from Hela cells, treated with EGF or calf intestinal phosphatase (CIP), using GSK3ÃƒŸ (Phospho-Ser9) Antibody 35-1001.

Product code: 35-1001

Clonality :	Polyclonal
Application :	IHC, WB, IF
Reactivity :	Rat, Mouse, Human

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For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Format :	Purified
Amount :	100 µl
Isotype :	Rabbit IgG
Content :	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition :	Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.


Gene :	GSK3B
Gene ID :	2932
Uniprot ID :	P49841
Alternative Name :	Factor A, GSK-3 beta, Protein kinase GSK-3-beta, kinase GSK-3 beta
Immunogen Information :	Peptide sequence around phosphorylation site of serine 9 (T-T-S(p)-F-A) derived from Human GSK3 beta.

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin.

Predicted MW: 46kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cytoplasm, Nucleus, Cell membrane
Post transnational modification:	Mono-ADP-ribosylation by PARP10 negatively regulates kinase activity.
Tissue Specificity:	Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain.
BioGrid:	109187. 294 interactions.