Polyclonal Antibody to eNOS (Ab-495)

Product code: 35-1570

Clonality : Polyclonal
Application : IF
Reactivity : Human, Mouse, Rat

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Available Pack Size(s)

  •   50 µl

  •  100 µl

  • $374.00 

  • $437.00 

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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : NOS3
Gene ID : 4846
Uniprot ID : P29474
Alternative Name : Constitutive NOS, EC-NOS, ECNOS, NOS3, NOSIII
Immunogen Information : Peptide sequence around aa.493~497 (K-K-T-F-K) derived from Human eNOS.
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

Predicted MW: 140kd, Immunofluorescence: 1:100~1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane, Membrane, Cytoplasm, Golgi apparatus
Post transnational modification: Phosphorylation by AMPK at Ser-1177 in the presence of Ca(2+)-calmodulin (CaM) activates activity. In absence of Ca(2+)-calmodulin, AMPK also phosphorylates Thr-495, resulting in inhibition of activity (By similarity). Phosphorylation of Ser-114 by CDK5 reduces activity.
Tissue Specificity: Platelets, placenta, liver and kidney.
BioGrid: 110909. 46 interactions.
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