Polyclonal Antibody to EGFR (Phospho-Thr678)

Product code: 35-1176

Clonality : Polyclonal
Application : WB, IHC
Reactivity : Human, Mouse, Rat

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Available Pack Size(s)

  •   50 µl

  •  100 µl

  • $374.00 

  • $437.00 

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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : EGFR
Gene ID : 1956
Uniprot ID : P00533
Alternative Name : ERBB1, Receptor protein-tyrosine kinase ErbB-1, kinase EGFR
Immunogen Information : Peptide sequence around phosphorylation site of threonine 678 (K-R-T(p)-L-R) derived from Human EGFR.
Receptor for EGF, but also for other members of the EGF family, as TGF-a, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin. Doherty JK, et al. (1999) Proc Natl Acad Sci U S A; 96(19): 10869-10874 Wu TT, et al. (1998) Mol Biol Cell; 9(7): 1661-1674 O

Predicted MW: 175kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Secreted
Post transnational modification: Methylated. Methylation at Arg-1199 by PRMT5 stimulates phosphorylation at Tyr-1197.
Tissue Specificity: Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.
BioGrid: 108276. 1217 interactions.
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