Polyclonal Antibody to EGFR (Ab-678) (Discontinued)

Product code: 35-1531

Clonality : Polyclonal
Application : WB
Reactivity : Rat, Mouse, Human

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Format : Purified
Amount : 100 µg
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : EGFR
Gene ID : 1956
Uniprot ID : P00533
Alternative Name : Receptor tyrosine-protein kinase ErbB-1, ERBB1
Immunogen Information : Peptide sequence around aa.676~680 (K-R-T-L-R) derived from Human EGFR.

Receptor for EGF, but also for other members of the EGF family, as TGF-a, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentia

Predicted MW: 175kd, Western blotting: 1:500~1:1000

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Secreted
Post transnational modification: Methylated. Methylation at Arg-1199 by PRMT5 stimulates phosphorylation at Tyr-1197.
Tissue Specificity: Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.
BioGrid: 108276. 1217 interactions.
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