Polyclonal Antibody to DEPTOR/DEPDC6
Fig-1: Western blot analysis DEPTOR. Anti-DEPTOR antibody (11-1021) was used at 2 µg/ml on HepG2 lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein A Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
DEPTOR is an mTOR inhibitor whose expression is negatively regulated by mTOR. DEPTOR expression is required to maintain PI3K and Akt activation and to inhibit apoptosis. DEPTOR is expressed in different microvascular ECs (endothelial cells). It plays a key role in maintaining stem cell pluripotency by limiting mTOR activity in undifferentiated embryonic stem cells (ESCs). It is overexpressed in RPMI-8226 human multiple myeloma cells, and plays an important role in maintaining cell survival.
Western blot analysis: 2-4 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Post transnational modification: | Ubiquitinated; ubiquitination leads to proteasomal degradation. |
| BioGrid: | 122304. 24 interactions. |
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