Polyclonal Antibody to CLEC8A
Fig-1: Western blot analysis of CLEC8A. Anti-CLEC8A antibody (11-4053) was used at 5 µg/ml on Brain lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein A Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
CLEC8A or OLR1 is a member of C-type lectin super family. It is the receptor that mediates the recognition and degradation of low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in inflammatory responses, pro-oxidative conditions and apoptosis. OLR1 ligation with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, Monocyte adhesion and apoptosis. OLR1 is highly expressed in vascular rich organs, like placenta, liver, lungs and brain. CLEC8A has been reported to be associated with diseases, like atherosclerosis, myocardial infarction and Alzheimer's disease. Alternative splicing produces three isoforms of CLEC8A or OLR1 whose exact function is yet to be ascertained.
Western blot analysis: 5-6 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Cell membrane, Membrane raft, Secreted |
| Post transnational modification: | N-glycosylated. |
| Tissue Specificity: | Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level. |
| BioGrid: | 111021. 3 interactions. |
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