Polyclonal antibody to CARD8 (Tucan)

Product code: 20-1105

Clonality : Polyclonal
Application : WB, IHC, IP
Reactivity : Human

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Size
Price
50 µl
$260.00 

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Shipping Info:

Order now and get it on Friday November 29, 2024

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Format : Sera
Amount : 50 µl
Isotype : Rabbit IgG
Content : 50 µl sera
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : CARD8
Gene ID : 22900
Uniprot ID : Q9Y2G2
Alternative Name : CARD8, KIAA0955, NDPP1
Immunogen Information : A synthetic peptide of human TUCAN (CARD8) (amino acids 125-146 LVGGPLFDVTAEPEEAVAEIHL) was used as immunogen for this antibody
This antibody recognizes TUCAN, a 431 amino acid protein. TUCAN (tumor up-regulated CARD-containing antagonist of caspase nine) also known as CARD8 is a CARD domain containing protein. Proteins containing a CARD (caspase-associated recruitment domain) domain are key regulators of cell death, cell survival and cytokine production. TUCAN is an anti-apoptotic CARD protein that can protect tumors from cell death stimuli, and is overexpressed in certain forms of cancer. TUCAN has been shown to inhibit caspase-9 activation by binding to the CARD region of pro-caspase-9, thereby suppressing the formation of the Apaf-1-caspase-9 apoptotic complex and apoptosis. Additionally, a TUCAN isoform has been described that blocks both caspase-8 and caspase-9 mediated apoptosis. However, in some tumors, TUCAN play a role in modulating NFkB transcription factor survivial signaling pathways.

WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Nucleus
Tissue Specificity: High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow.
BioGrid: 116564. 45 interactions.
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