Polyclonal Antibody to CaMKII (Phospho-Thr286)
Figure 1: Western blot analysis of extracts from 293 cells untreated or treated with PMA using CaMKII(Phospho-Thr286) Antibody 35-1262 .
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Shipping Info:
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity Pak JH, et al. Proc Natl Acad Sci U S A. 2000 Oct 10; 97(21): 11232-11237 Hudmon A, et al. J Cell Biol. Author manuscript; available in PMC 2006 May 7 Miller P, et al. PLoS Biol. 2005 Apr; 3(4): e107 Runyan JD, et al. Learn Mem. 2005 Mar; 12(2): 103-110.
Predicted MW: 50kd, Western blotting: 1:500~1:1000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell junction, Cell junction, Cell projection, Cell projection |
| Post transnational modification: | Autophosphorylation of Thr-286 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-286 locks the kinase into an activated state. |
| BioGrid: | 107265. 57 interactions. |
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