Polyclonal Antibody to Bub3 (Phospho-Tyr207)
Figure 1: Western blot analysis of Bub3 (Phospho-Tyr207)Antibody 35-1351 (arrow indicated) in U87 (A) and U87 EGFRvIII (B) cells in Mitosis.
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Gene : | BUB3 |
| Gene ID : | 9184 |
| Uniprot ID : | O43684 |
| Alternative Name : | Mitotic checkpoint protein BUB3, Hbub3, BUB3L, BUB3 budding uninhibited by benzimidazoles 3 homolog, budding uninhibited by benomyl |
| Immunogen Information : | Peptide sequence around phosphorylation site of Tyrosine 207 (V-E-Y(p)-L-D) derived from Human Bub3. |
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Western blotting: 1:1000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Chromosome |
| Post transnational modification: | Poly-ADP-ribosylated by PARP1. |
| BioGrid: | 114621. 86 interactions. |
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