Polyclonal Antibody to Beta Tubulin
Figure-1: Western blot analysis of Beta Tubulin. Anti- Beta Tubulin antibody (11-13002) was used at 4 µg/ml on 1) A431, 2) Hela, 3) MCF7 and 4) 3T3 lysates.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein A Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Tubulin is one of several members of a small family of globular proteins and is the major constituent of microtubules. The most common members of the tubulin family are alpha-tubulin and beta-tubulin. It appears to play an important role in the formation of platelet. It is involved in the pathogenesis of Cortical dysplasia, complex, with other brain malformations 6 (CDCBM6) and distal hereditary motor neuropathy, type 2. Ubiquitously expressed with highest levels in spleen, thymus and immature brain. It is expressed exclusively in megakaryocytes and platelets in humans.
Western blot analysis: 4-6 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm |
| Post transnational modification: | Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules. |
| Tissue Specificity: | High expression in brain, where it represents 30% of all beta-tubulins. |
| BioGrid: | 113131. 128 interactions. |
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