Polyclonal Antibody to Beta-arrestin 1

Product code: 11-8059

Clonality : Polyclonal
Application : WB
Reactivity : Human

Shipping Info:

Order now and get it on Tuesday November 26, 2024

Write a review for this product on BioCompare
Get $20 gift card from Amazon
Size
Price

Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $100.00 

  • $270.00 

Add to Wish List

Shipping Info:

Order now and get it on Tuesday November 26, 2024

Same day delivery FREE on San Diego area orders placed by 1.00 PM


Format : Purified
Amount : 100 µg
Isotype : Rabbit IgG
Purification : Protein A Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : ARRB1
Gene ID : 408
Uniprot ID : P49407
Alternative Name : ARRB1, ARR1
Immunogen Information : A partial length recombinant Beta-arrestin 1 protein (amino acids 150-318) was used as the immunogen for this antibody.
Beta-arrestin 1, a member of arrestin family, is a cofactor of beta-adrenergic receptor kinase (BARK) in beta-adrenergic receptor desensitization and resensitization process. Beta-arrestin 1 acts as endocytic adapter for internalization of many G-protein coupled receptors. Beta-arrestin 1 is also associated with many other cellular processes like ubiquitination and down-regulation of the insulin-like growth factor-1 receptor, synaptic transmission in photoreceptor cells, working as a scaffold protein in G-protein coupled receptor signaling pathways. Two isoforms of beta-arrestin 1 have been identified, isoform 1 (47 kDa) and isoform 2 (46 kDa). Beta-arrestin 1 is highly expressed in liver, kidney, lungs and testes.

Western blot analysis: 2-4 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Nucleus, Cell membrane, Membrane, Cell projection, Cytoplasmic vesicle
Post transnational modification: The ubiquitination status appears to regulate the formation and trafficking of beta-arrestin-GPCR complexes and signaling. Ubiquitination appears to occur GPCR-specific. Ubiquitinated by MDM2; the ubiquitination is required for rapid internalization of ADRB2. Deubiquitinated by USP33; the deubiquitination leads to a dissociation of the beta-arrestin-GPCR complex. Stimulation of a class A GPCR, such as ADRB2, induces transient ubiquitination and subsequently promotes association with USP33.
BioGrid: 106901. 259 interactions.
There are currently no product reviews

Customers who purchased this product also purchased

Most viewed Products