Polyclonal Antibody to ASAP1
Fig-1: Western blot analysis of ASAP1. Anti-ASAP1 antibody (11-8069) was used at 4 µg/ml on Pancrease lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein A Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Gene : | ASAP1 |
| Gene ID : | 50807 |
| Uniprot ID : | Q9ULH1 |
| Alternative Name : | 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein, ADP-ribosylation factor-directed GTPase-activating protein 1, Development and differentiation-enhancing factor 1, PIP2-dependent ARF1 GAP, DDEF1, KIAA1249 |
| Immunogen Information : | A partial length recombinant ASAP1 protein (amino acids 912-1115) was used as the immunogen for this antibody. |
ASAP (Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1) or Development and differentiation-enhancing factor 1 or DDEF1 is an ADP-ribosylation factor (ARF) GTPase-activating protein with two known isoforms: ASAP1a and ASAP1b (125 and 126 kDa, respectively). ASAP contains a pleckstrin homology (PH) domain, a zinc finger motif, 3 ankyrin repeats, a proline-rich region containing several SH3 ligand motifs, and an SH3 domain. GTPase-activating property of ASAP1 is induced by phosphatidylinositol 4,5-biphosphate (PIP2) of the PH domain. ASAP1 plays an important role in cytoskeleton remodeling and regulation of membrane trafficking. ASAP1 acts as a proto-oncogene in breast cancer and other malignant tumors. ASAP is highly expressed in brain tissue.
Western blot analysis: 2-4 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Membrane |
| Post transnational modification: | Phosphorylated on tyrosine residues by SRC. |
| Tissue Specificity: | Expressed in all tissues examined but a most abundant expression was found in the testis, brain, lung and spleen. A heightened expression was seen in the adipose tissue from obese (ob) and diabetic (db) animals. |
| BioGrid: | 199076. 21 interactions. |
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