Polyclonal Antibody to ASAP1

Fig-1: Western blot analysis of ASAP1. Anti-ASAP1 antibody (11-8069) was used at 4 µg/ml on Pancrease lysate.

Roll over image to zoom in

Product code: 11-8069

Clonality :	Polyclonal
Application :	WB
Reactivity :	Human

Shipping Info:

Order now and get it on Wednesday July 03, 2024

Download TDS MSDS

Write a review for this product on BioCompare

Get $20 gift card from Amazon

Shipping Info:

Order now and get it on Wednesday July 03, 2024

Same day delivery FREE on San Diego area orders placed by 1.00 PM

Download TDS MSDS

Format :	Purified
Amount :	100 µg
Isotype :	Rabbit IgG
Purification :	Protein A Chromatography
Content :	25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition :	Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.


Gene :	ASAP1
Gene ID :	50807
Uniprot ID :	Q9ULH1
Alternative Name :	130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein, ADP-ribosylation factor-directed GTPase-activating protein 1, Development and differentiation-enhancing factor 1, PIP2-dependent ARF1 GAP, DDEF1, KIAA1249
Immunogen Information :	A partial length recombinant ASAP1 protein (amino acids 912-1115) was used as the immunogen for this antibody.

ASAP (Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1) or Development and differentiation-enhancing factor 1 or DDEF1 is an ADP-ribosylation factor (ARF) GTPase-activating protein with two known isoforms: ASAP1a and ASAP1b (125 and 126 kDa, respectively). ASAP contains a pleckstrin homology (PH) domain, a zinc finger motif, 3 ankyrin repeats, a proline-rich region containing several SH3 ligand motifs, and an SH3 domain. GTPase-activating property of ASAP1 is induced by phosphatidylinositol 4,5-biphosphate (PIP2) of the PH domain. ASAP1 plays an important role in cytoskeleton remodeling and regulation of membrane trafficking. ASAP1 acts as a proto-oncogene in breast cancer and other malignant tumors. ASAP is highly expressed in brain tissue.

Western blot analysis: 2-4 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cytoplasm, Membrane
Post transnational modification:	Phosphorylated on tyrosine residues by SRC.
Tissue Specificity:	Expressed in all tissues examined but a most abundant expression was found in the testis, brain, lung and spleen. A heightened expression was seen in the adipose tissue from obese (ob) and diabetic (db) animals.
BioGrid:	199076. 21 interactions.