Anti-SOCS1 Polyclonal Antibody
Figure 1: Anti-SOCS1 antibody(39-2061). Western blotting : Lane 1: HT1080 Cell Lysate , Lane 2: COLO320 Cell Lysate.
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Shipping Info:
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| Format : | Lyophilized |
| Amount : | 100 μg/vial |
| Isotype : | Rabbit IgG |
| Purification : | Immunogen affinity purified. |
| Content : | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitute : Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Storage condition : | At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing. |
| Gene : | SOCS1 |
| Gene ID : | 8651 |
| Uniprot ID : | O15524 |
| Alternative Name : | Suppressor of cytokine signaling 1; SOCS-1; JAK-binding protein; JAB; STAT-induced STAT inhibitor 1; SSI-1; Tec-interacting protein 3; TIP-3; SOCS1; SSI1, TIP3 |
| Immunogen Information : | A synthetic peptide corresponding to a sequence at the C-terminus of human SOCS1(197-211aa NPVLRDYLSSFPFQI), identical to the related mouse and rat sequences. |
Suppressor of cytokine signaling 1(SOCS1), also known as Jak-binding protein(JAB), is a negative regulator to a subset of protein-tyrosine kinases. This 211-amino acid protein has a molecular mass of about 23.5 kD. The TEC-binding region of SOCS1 resides in the N terminus. SOCS1 associates with Tec and suppresses its kinase activity. The SOCS1 gene is intronless and is mapped to on chromosome 16p13.13. SOCS1 regulates the JAK/STAT signal-transduction pathway. Moreover, it contributes to protection against hepatic injury and fibrosis, and may also protect against hepatocarcinogenesis.
Western blot : 0.1-0.5μg/ml; Immunohistochemistry(Paraffin-embedded Section) : 0.5-1μg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Cytoplasmic vesicle |
| Tissue Specificity: | Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes. |
| BioGrid: | 114203. 57 interactions. |
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