Anti-Kv1.1 potassium channel Polyclonal Antibody
Figure 1: Anti-Kv1.1 potassium channel antibody(39-2150). Western blotting: Lanes: Anti-KCNA1(39-2150) at 0.5ug/ml. Lane 1: Rat Brain Tissue Lysate at 40ug, Lane 2: Rat Testis Tissue Lysate at 40ug, Lane 3: Rat Cardiac Muscle Tissue Lysate at 40ug, Lane 4: HELA Whole Cell Lysate at 40ug, Lane 5: U87 Whole Cell Lysate at 40ug, Lane 6: SHG Whole Cell Lysate at 40ug, Lane 7: NEURO Whole Cell Lysate at 40ug. Predicted band size: 56 kDa. Observed band size: 56 kDa.
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| Format : | Lyophilized |
| Amount : | 100 μg/vial |
| Isotype : | Rabbit IgG |
| Purification : | Immunogen affinity purified. |
| Content : | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitute : Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Storage condition : | At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing. |
| Gene : | KCNA1 |
| Gene ID : | 3736 |
| Uniprot ID : | Q09470 |
| Alternative Name : | Potassium voltage-gated channel subfamily A member 1; Voltage-gated K(+) channel HuKI ; Voltage-gated potassium channel HBK1 ; Voltage-gated potassium channel subunit Kv1.1; KCNA1 |
| Immunogen Information : | A synthetic peptide corresponding to a sequence at the C-terminus of human Kv1.1 potassium channel(465-481aa IAHYRQVNIRTANCTTA), different from the related mouse sequence by two amino acids, and from the related rat sequence by four amino acids . |
Potassium voltage-gated channel subfamily A member 1, also known as Kv1.1, is a shaker related voltage-gated potassium channel that in humans is encoded by the KCNA1 gene. It is mapped to 12p13.32. The protein functions as a potassium selective channel through which the potassium ion may pass through in consensus with the electrochemical gradient. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting.
Western blot : 0.1-0.5μg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Membrane, Cell projection, Cytoplasmic vesicle, Perikaryon, Endoplasmic reticulum, Cell projection, Cell junction, Cell junction, Cell junction |
| Post transnational modification: | Phosphorylated on tyrosine residues. Phosphorylation increases in response to NRG1; this inhibits channel activity (By similarity). Phosphorylation at Ser-446 regulates channel activity by down-regulating expression at the cell membrane (PubMed:23774215). |
| Tissue Specificity: | Detected adjacent to nodes of Ranvier in juxtaparanodal zones in spinal cord nerve fibers, but also in paranodal regions in some myelinated spinal cord axons (at protein level) (PubMed:11086297). Detected in the islet of Langerhans (PubMed:21483673). |
| BioGrid: | 109939. 7 interactions. |
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