Polyclonal Antibody to Alpha-Synuclein (Ab-133)

Product code: 35-1607

Clonality : Polyclonal
Application : WB, IF
Reactivity : Rat, Mouse, Human

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  •   50 µl

  •  100 µl

  • $374.00 

  • $437.00 

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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : SNCA
Gene ID : 6622
Uniprot ID : P37840
Alternative Name : NACP, SYN, SYUA, alpha-synuclein
Immunogen Information : Peptide sequence around aa. 131~135 (E-G-Y-Q-D) derived from Human a-Synuclein.

May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

Predicted MW: 18kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Membrane, Nucleus, Cell junction, Secreted
Post transnational modification: Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.
Tissue Specificity: Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain.
BioGrid: 112506. 474 interactions.
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