Polyclonal Antibody to Alpha-Synuclein (Ab-133)
Figure 1: Western blot analysis of extracts from Hela cells using a-Synuclein(Ab-133) Antibody 35-1607 .
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Predicted MW: 18kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Membrane, Nucleus, Cell junction, Secreted |
| Post transnational modification: | Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure. |
| Tissue Specificity: | Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain. |
| BioGrid: | 112506. 474 interactions. |
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