Polyclonal Antibody to ALDH1A1

Product code: 11-7549

Clonality : Polyclonal
Application : WB
Reactivity : Human

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Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $100.00 

  • $270.00 

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Format : Purified
Amount : 100 µg
Isotype : Rabbit IgG
Purification : Protein A Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : ALDH1A1
Gene ID : 216
Uniprot ID : P00352
Alternative Name : ALDH1A1, ALDC, ALDH1, PUMB1
Immunogen Information : A partial length recombinant ALDH1A1 protein (amino acids 284-492) was used as the immunogen for this antibody.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a member of a superfamily of detoxification enzymes found in various tissues that participate in the oxidation of both aliphatic and aromatic aldehydes. The human ALDH1A1, which is tetrameric and predominantly of cytosolic origin, functions mainly in acetaldehyde and neurotransmitter metabolism. It is also reported to play a major role in the production of retinoic acid, which is important for gene expression and tissue differentiation, and also in cyclophosphamide detoxification. ALDH1A1 is found in various tissues, including the central nervous system (CNS), with highest levels in the liver. In the brain, ALDH1A1 participates in the metabolism of catecholamines including dopamine (DA) and norepinephrine, and is uniquely expressed in a subset of dopaminergic (DAergic) neurons in the ventral mesencephalon where it converts 3,4-dihydroxyphenylacetaldehyde, a potentially toxic aldehyde, to 3,4-dihydroxyphenylacetic acid, a non toxic metabolite. ALDHA1 has been implicated in the development of alcohol dependence and other alcohol-use disorders, alcohol-induced flushing and sensitivity to alcohol.

Western blot analysis: 1-2 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm
Post transnational modification: The N-terminus is blocked most probably by acetylation.
BioGrid: 106718. 6 interactions.
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