Phospho-Stat6 (Tyr641) (Clone: G12) rabbit mAb PE conjugate
Fig-1: Flow cytometric analysis of U937 cells unstained and untreated cells as negative control (blue) or stained and untreated (red) or treated with IFNa and IL-4 (green) using Phospho-Stat6 (Tyr641)-G12 antibody Stat6Y641-G12 PE conjugate.
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| Format : | Conjugated |
| Amount : | 100 Tests |
| Isotype : | Rabbit IgG1k |
| Content : | 1X PBS, 0.09% NaN3, 0.2% BSA |
| Storage condition : | Store at 2-8°C. Avoid repeated freeze and thaw cycles. |
| Alternative Name : | Signal transducer and activator of transcription 6, IL-4 Stat |
| Immunogen Information : | A synthetic phospho-peptide corresponding to residues surrounding Tyr641 of human phospho Stat6 |
The transcription factor Stat6 is a member of the signal transducers and activators of transcription (STAT) family of proteins. Stat6 is the only member of this family that is activated by interleukin-4 (IL-4), after which Stat6 is both tyrosine- and serine-phosphorylated by Jak kinases. The consensus Stat6 binding site TTCN4GAA is found in the promoters of many genes regulated by IL-4. In T lymphocytes, Stat6 is required for differentiation into Th2 cells in response to IL-4. Stat6 may play a role in solid tumorigenesis; a large immunohistochemistry study of Stat6 expression in over 2,000 tumor samples confirmed strong nuclear staining.
For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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