Phospho-Stat4 (Tyr693) (Clone: F6) rabbit mAb APC conjugate(Discontinued)

Product code: 12-4234

Clone name : Stat4Y693-F6
Clonality : Monoclonal
Application : FACS
Reactivity : Human, Mouse
Conjugate : APC

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Format : Conjugated
Amount : 100 Tests
Isotype : Rabbit IgG1k
Content : 1X PBS, 0.09% NaN3, 0.2% BSA
Storage condition : Store at 2-8°C. Avoid repeated freeze and thaw cycles.
Alternative Name : Signal transducer and activator of transcription 4
Immunogen Information : A synthetic phospho-peptide corresponding to residues surrounding Tyr693 of human phospho Stat4
In response to IL-12 binding, the IL-12 receptor activates the Jak kinases, which phosphorylate tyrosine residues of IL-12RB2. These phosphorylated receptors recruit Stat4 through its SH2 domain, whereupon Stat4 is phosphorylated at Tyr693 in its C-terminal transactivation domain. Phosphorylation promotes Stat4 homodimerization and translocation to the nucleus, where it promotes gene transcription. The N-terminal domain of Stat4 appears to be required for maximal stabilization and for the binding of Stat4 dimers to lower-affinity DNA binding sites. Stat4-deficient mice have demonstrated that this gene is required to both promote Th1 development and inhibit Th2 differentiation due to disabling IL-12 receptor-mediated responses.

For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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