Phospho-Stat1 (Tyr701) (Clone: 3E6) rabbit mAb

Product code: 12-4106

Clone name : Stat1Y701-3E6
Clonality : Monoclonal
Application : FACS
Reactivity : Human, Mouse
Conjugate : Unconjugated

Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Write a review for this product on BioCompare
Get $20 gift card from Amazon
Size
Price

Available Pack Size(s)

  •   20 µl

  •  200 µl

  • $482.00 

  • $837.00 

Add to Wish List

Shipping Info:

For estimated delivery dates, please contact us at [email protected]


Format : Purified
Amount : 200 µl
Isotype : Rabbit IgG1k
Content : 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Storage condition : Store at -20°C. Avoid repeated freeze and thaw cycles.
Alternative Name : Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84
Immunogen Information : A synthetic phospho-peptide corresponding to residues surrounding Tyr701 of human phospho Stat1
Stat1 mediates the cellular response to IFN alpha, IFNB, and IFNg for the regulation of cell growth and the defense against viral and immune challenges. The Jak-Stat pathway plays a central role in the IFNg response, where Stat1 phosphorylation on Tyr701 causes homodimerization through its SH2 domain, translocation to the nucleus, and binding to gamma-activated sequence (GAS) elements. Early in the activation sequence, Stat1 is also phosphorylated at Ser727 through a mechanism involving PI3 kinase and Akt. Stat1 has been found to correlate with increased resistance to chemotherapeutic drugs. However, Stat1 activation of the immune system helps suppress tumor growth, and multiple melanomas and squamous-cell carcinomas have been known to downregulate Stat1 expression to evade immune surveillance.

1µg/mL - 0.001µg/mL. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.(0.5mg/ml)

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

There are currently no product reviews

Customers who purchased this product also purchased

Most viewed Products