Phospho-SLP-76 (Tyr128) (Clone: 3F8) rabbit mAb

Product code: 12-4084

Clone name : SLP76Y128-3F8
Clonality : Monoclonal
Application : FACS
Reactivity : Human, Mouse
Conjugate : Unconjugated

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Available Pack Size(s)

  •   20 µl

  •  200 µl

  • $482.00 

  • $837.00 

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For estimated delivery dates, please contact us at [email protected]


Format : Purified
Amount : 200 µl
Isotype : Rabbit IgG1k
Content : 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Storage condition : Store at -20°C. Avoid repeated freeze and thaw cycles.
Alternative Name : Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP76, LCP2
Immunogen Information : A synthetic phospho-peptide corresponding to residues surrounding Tyr128 of human phospho SLP-76
SH2 Domain-Containing Leukocyte Protein Of 76 KDa (SLP-76) is an adaptor protein that plays a role in signal transduction in T cells. Studies using a SLP-76-deficient T cell line have demonstrated that SLP-76 is required for optimal phosphorylation and activation of both PLCg1 and the Ras pathway. SLP-76 phosphorylation is mediated by Zap70 upon TCR stimulation. Within an N-terminal acidic region, SLP-76 possesses three tyrosines (Tyr113, 128, and 145), which are phosphorylated upon activation. The sterile alpha-motif (SAM) domain of SLP-76 drives formation of dimers and higher order oligomers. SLP-76 micro-clusters at the immunological synapse enhance signal transduction and T cell activation.

1µg/mL - 0.001µg/mL. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.(0.5mg/ml)

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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