Phospho-S6 Ribosomal Protein (Ser235/236) (Clone: R3A2) rabbit mAb
Fig-1: Flow cytometric analysis of U937 cells secondary antibody only negative control (blue) or treated with U0126 plus SB20350 (red) or treated with TPA plus calyculin A (green) using Phospho-S6 ribosomal protein (Ser235/Ser236) antibody S6S235S236-R3A2.
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| Format : | Purified |
| Amount : | 200 µl |
| Isotype : | Rabbit IgG1k |
| Content : | 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA |
| Storage condition : | Store at -20°C. Avoid repeated freeze and thaw cycles. |
| Alternative Name : | 40S ribosomal protein S6, Phosphoprotein NP33, Small ribosomal subunit protein eS6, RPS6 |
| Immunogen Information : | A synthetic phospho-peptide corresponding to residues surrounding Ser235/236 of human phospho S6 Ribosomal Protein |
Ribosomal protein S6 kinase is one of two parallel signaling pathways downstream of mTOR, with the other being 4E-BP1. mTOR phosphorylates and activates S6 kinase, which then phosphorylates ribosomal protein S6. The pathway regulates cell growth and cell cycle progression. The identified phosphorylation sites of S6 are Ser235, Ser236, Ser240, Ser244, and Ser247, which are evolutionarily conserved in higher eukaryotes. Ser236 has been proposed as the primary phosphorylation site. Studies using S6 knockin mice, where all five phosphorylation site serine residues are replaced by alanine, have provided extensive detail on S6 function. These studies support the role phosphorylated S6 plays in regulation of cell size, glucose homeostasis, and protein synthesis.
1µg/mL - 0.001µg/mL. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.(0.5mg/ml, more than 200 western blots)
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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