Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Clone: A11) rabbit mAb FITC conjugate

Product code: 12-4006

Clone name : ERK12T202Y204-A11
Clonality : Monoclonal
Application : FACS
Reactivity : Human, Mouse
Conjugate : FITC

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  •   10 Tests

  •  100 Tests

  • $392.00 

  • $629.00 

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Format : Conjugated
Amount : 100 Tests
Isotype : Rabbit IgG1k
Content : 1X PBS, 0.09% NaN3, 0.2% BSA
Storage condition : Store at 2-8°C. Avoid repeated freeze and thaw cycles.
Alternative Name : Mitogen-activated protein kinase 3, MAPK3, ERK2, p44-MAPK, PRKM3, Mitogen-activated protein kinase 1, MAPK1, ERK1, p42-MAPK, PRKM1, PRKM2
Immunogen Information : A synthetic phospho-peptide corresponding to residues surrounding Thr202/Tyr204 of human phospho Erk1/2.
Human Erk1 and Erk2 Ser/Thr kinases share 84% sequence identity and nearly all functions. These MAP kinases are activated in response to mitogens and growth factors as part of the Ras-Raf-MEK-ERK signal transduction cascade. This pathway regulates cell survival, differentiation, adhesion, cell cycle progression, and many other cellular processes. Upon phosphorylation, Erk1/2 translocate to the nucleus to activate transcription factors including c-Fos, Elk1, Ets1, and SP-1. There are more than 175 known cytoplasmic and nuclear substrates of Erk1/2. The Erk1/2 cascade is upregulated in many human cancers, even when oncogenic mutations are not found. Multiple small-molecule inhibitors of Erk1/2 have been developed, including ones targeting the ATP-binding site either competitively or irreversibly.

For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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