Phospho-MKK7 (Ser271/Thr275) (Clone: R4F9) rabbit mAb

Product code: 12-4088

Clone name : MKK7S271T275-R4F9
Clonality : Monoclonal
Application : FACS, WB
Reactivity : Human, Mouse, Rat
Conjugate : Unconjugated

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Price

Available Pack Size(s)

  •   20 µl

  •  200 µl

  • $482.00 

  • $837.00 

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Shipping Info:

For estimated delivery dates, please contact us at [email protected]


Format : Purified
Amount : 200 µl
Isotype : Rabbit IgG1k
Content : 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Storage condition : Store at -20°C. Avoid repeated freeze and thaw cycles.
Alternative Name : Dual specificity mitogen-activated protein kinase kinase 7, MAP kinase kinase 7, MAPKK 7, JNK-activating kinase 2, MAPK/ERK kinase 7, Stress-activated protein kinase kinase 4, SAPK kinase 4, SAPKK4, c-Jun N-terminal kinase kinase 2, JNK kinase 2, MAP2K7, JNKK2, MEK7, PRKMK7, SKK4
Immunogen Information : A synthetic phospho-peptide corresponding to residues surrounding Ser271/Thr275 of human phospho MKK7
MKK7 is a dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. It is an essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that phospho MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Phospho MKK7 has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

1µg/mL - 0.001µg/mL. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.(0.5mg/ml, more than 200 western blots)

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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