Phospho-Lamin A/C (Ser22) (Clone: CF12) rabbit mAb
Fig-1: Flow cytometric analysis of HeLa cells, secondary antibody only negative control (blue), or untreated (grey) or treated with nocodazole (orange) using 0.01 µg/mL isotype control or untreated (red) or treated (green) using Phospho-Lamin A/C (Ser22) antibody LaminACS22-CF12 at 0.01 µg/mL.
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| Format : | Purified |
| Amount : | 200 µl |
| Isotype : | Rabbit IgG1k |
| Content : | 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA |
| Storage condition : | Store at -20°C. Avoid repeated freeze and thaw cycles. |
| Alternative Name : | Prelamin-A/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMNA, LMN1 |
| Immunogen Information : | A synthetic phospho-peptide corresponding to residues surrounding Ser22 of human phospho Lamin A/C |
Lamins are nuclear membrane proteins that are involved with cell cycle control, chromatin organization, and DNA replication (1,2). Upon caspase 6 cleavage, lamin A/C serves as a molecular marker for capspase 6 activity. Lamin A/C is cleaved during cellular apoptosis into a large (41-50 kDa) as well as a small (28 kDa) fragment leading to nuclear dysfunction and cell death (3) Phosphorylation of lamin A/C at Ser32 by MAPK/CDK signals cell cycle progression and mitosis (4,5).
1µg/mL - 0.001µg/mL. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.(0.5mg/ml, more than 200 western blots)
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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