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Gene : |
IGHM |
Uniprot ID : |
P01871
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Alternative Name : |
Immunoglobulin heavy constant mu |
Immunogen Information : |
Purified human IgM. |
Immunoglobulin M (IgM) is produced as a 900 kDa pentamer, which is an efficient complement binder. This antibody type is produced initially in the immune response and it is the first immunoglobulin class to be synthesized by a fetus or newborn. IgM antibodies do not cross the placenta. IgM concentration in blood is 0.12 g/l and its biological survival (plasma T1/2) is 5 days.
Subcellular location: |
Cell membrane |
Post transnational modification: |
Not N-glycosylated (PubMed:23236605). Probably not O-glycosylated (PubMed:23236605). |
Tissue Specificity: |
Expressed in spleen, lymph node, thymus, bone marrow, and fetal liver, but not in non-lymphoid tissues. |
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