PerCP-Cy™5.5 Conjugated Anti-CD79a Monoclonal Antibody (Clone:HM47)

Product code: 30-1528PC-Cy5.5

Clone name : HM47
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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100 Tests
$550.00 

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Format : Purified
Amount : 100 Tests
Isotype : Mouse IgG1
Purification : Purified antibody is conjugated with activated tandem dye of activated Peridinin-Chlorophyll Protein-Cyanine 5.5 (PerCP-Cy™5.5) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Content : Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage condition : Store at 2-8°C protected from light. Do not freeze.
Gene : CD79A
Gene ID : 973
Uniprot ID : P11912
Alternative Name : CD79A, IGA, MB1
Immunogen Information : Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a

CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.

Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests. Intracellular staining.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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