PE Conjugated Anti-Perforin Monoclonal Antibody (Clone:dG9)
Figure 1: Intracellular staining of perforin in human peripheral blood cells with anti-perforin (dG9) PE.
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| Amount : | 100 tests |
| Isotype : | Mouse IgG2b |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
Perforin is a 70 kDa cytolytic protein with structural and functional similarities to complement component 9 (C9). It is stored in cytoplasmic granules of cytotoxic T cells and NK cells and after its release it forms transmembrane pores in the target cells to kill it. As perforin is a key effector molecule for cell-mediated cytolysis, defects of its gene can cause severe disorders.
| Subcellular location: | Cytoplasmic granule lumen, Secreted, Cell membrane, Endosome lumen |
| Post transnational modification: | N-glycosylated. |
| BioGrid: | 111542. 5 interactions. |
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