PE conjugated Anti-Human LOX1 Mab (Clone: 15C4)
Figure 1: Separation of CD11c positive cells stained using anti-human LOX1 (15C4) PE antibody (10 μl reagent per million cells in 100 μl of cell suspension, red-filled) from CD11c positive cells cells stained using mouse IgG2a isotype control (MOPC-173) PE antibody (concentration in sample 5 μg/ml, same as LOX1 PE concentration, black-dashed) in flow cytometry analysis (surface staining) of human GM-CSF + IL-4 stimulated peripheral whole blood.
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Amount : | 100 tests |
Isotype : | Mouse IgG2a kappa |
Purification : | Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. |
Content : | Storage buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Storage condition : | Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze. |
Specificity: The mouse monoclonal antibody 15C4 recognizes an extracellular epitope of LOX1, a C-type lectin transmembrane protein.
LOX1, a 31 kDa type II transmembrane protein, is a C-type lectin, functioning as a scavenger receptor for e.g. oxidized low density lipoprotein, apoptotic heat shock proteins, or CRP. It is expressed by macrophages, fibroblasts, platelets, endothelial cells, and smooth muscle cells, and its defects can lead to atherosclerosis. Its expression is enhanced under inflammatory conditions. Multiple splicing variants have been identified.
Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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