Pacific Blue Conjugated Anti-CD105 / Endoglin Monoclonal Antibody (Clone:MEM-226)
Figure 1: Flow cytometry analysis (surface staining) of HUVEC (human umbilical vein endothelial cells) with anti-CD105 (MEM-226) Pacific Blue.
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| Amount : | 100 tests |
| Isotype : | Mouse IgG2a |
| Purification : | Purified antibody is conjugated with Pacific Blue NHS ester under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. |
| Content : | Formulation: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Storage condition : | Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze. |
CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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