NALE™ Monoclonal antibody to B7-H4 (Clone: ABM53A6) (No Azide, Low Endotoxin)

Product code: 10-4172-NALE

Clone name : ABM53A6
Clonality : Monoclonal
Application : IHC, FACS, WB
Reactivity : Mouse, Human
Conjugate : Unconjugated

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Order now and get it on Wednesday December 25, 2024

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Size
Price

Available Pack Size(s)

  •   25ug

  •  100 µg

  • $110.00 

  • $290.00 

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Shipping Info:

Order now and get it on Wednesday December 25, 2024

Same day delivery FREE on San Diego area orders placed by 1.00 PM


Format : Low Endotoxin,Azide Free,Purified
Amount : 100 µg
Isotype : Mouse IgG2a, k
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS. No Azide, Low Endotoxin
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : VTCN1
Gene ID : 79679
Uniprot ID : Q7Z7D3
Alternative Name : V-set domain-containing T-cell activation inhibitor 1, B7 homolog 4, B7h.5, Immune costimulatory protein B7-H4, Protein B7S1
Immunogen Information : A partial length recombinant protein (a.a 23-220) of B7-H4 was used as the immunogen for this antibody.

B7-H4, a member of B7 family, is a transmembrane protein that has been shown to inhibit T cell responses and neutrophil expansion during bacterial infections. B7-H4 mRNA is widely distributed in mouse and human peripheral tissues and can be induced in monocytes, macrophages, and dendritic cells upon IL-6 and IL-10 stimulation. However, in a variety of tumor cells, B7-H4 is predominantly present in intracellular compartments with unknown mechanism and functions. Cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. The overexpression of B7-H4 has been found in various types of human tumors, such as breast cancer, renal cell carcinoma (RCC), ovarian cancer, esophageal squamous cell carcinoma, gastric cancer, pancreatic cancer and melanoma etc, where its expression level is positively correlated with disease progression. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity.

FACS: 0.5-1  µg/10^6 cells; Immunohistochemical analysis: 5 µg/mlWestern blot analysis: 2-4 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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