Mouse Vascular Endothelial Growth Factor-165

Source: Genetically modified E.coli.
Predicted MW: Dimer, 19.4/38.8 kDa (165/230 aa)
Vascular endothelial growth factor A (VEGF-A) is produced by a wide variety of cell types, including tumor and vascular cells.  VEGF-A is a mediator of vascular growth, vascular permeability, and plays a role in stimulating vasodilation via nitric oxide-dependent pathways.  VEGF-A has several alternatively spliced isoforms, with VEGF-165 being the most abundant.  The VEGF-165 isoform is a secreted protein that acts on receptors VEGFR-1 and VEGFR-2 to modulate endothelial cell proliferation and angiogenesis.

Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Biological Activity was determined by HUVEC Proliferation at <=10 ng/mL; >= 1.0 x 10^5 units/mg (typical ED50 is < 5 ng/mL). Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cell membrane
Tissue Specificity:	In developing embryos, expressed mainly in the choroid plexus, paraventricular neuroepithelium, placenta and kidney glomeruli. Also found in bronchial epithelium, adrenal gland and in seminiferous tubules of testis. High expression of VEGF continues in kidney glomeruli and choroid plexus in adults.
BioGrid:	204512. 3 interactions.

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