Mouse TREM2 Protein, hFc Tag

Product code: 32-18524

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  •   50 µg

  •  100 µg

  • $485.00 

  • $591.00 

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Amount : 100 µg
Purification : The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Content : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.
Storage condition : Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Uniprot ID : Q99NH8
Alternative Name : TREM-2;Trem2a;Trem2b;Trem2c
Description :Recombinant mouse TREM2 protein with C-terminal human Fc tag
Background: The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
Description: Recombinant mouse TREM2 protein with C-terminal human Fc tag
Molecular Characterization: Mouse TREM2(Leu19-Ser171) hFc(Glu99-Ala330)
Molecular Weight :The protein has a predicted molecular mass of 42.9 kDa after removal of the signal peptide.
Tag :C-Human Fc Tag
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