Mouse RELM-gamma (AF)
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| Amount : | 100 µg |
| Purification : | Reducing and Non-Reducing SDS PAGE at >= 95% |
| Content : | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA) Sterile water at 0.1 mg/mL |
| Storage condition : | Store at -20°C |
| AA sequence : | MEGTLESIVE KKVKELLANR DDCPSTVTKT FSCTSITASG RLASCPSGMT VTGCACGYGC GSWDIRDGNT CHCQCSTMDW ATARCCQLA |
Source: Genetically modified E.coli.
Predicted MW:Â Dimer, 9.4 / 18.9 kDa (89 / 178 aa)
Resistin-like molecule-gamma (RELM-gamma ) is a member of the RELM family of secreted proteins containing C-terminal cysteines. The RELM family consists of Resistin (FIZZ3), RELM-alpha (FIZZ1), RELM-beta (FIZZ2), and RELM-gamma (FIZZ4). RELM-gamma is secreted by peripheral blood granulocytes, bone marrow, spleen, intestine, and lung. RELM-gamma functions to promote and regulate promyelocytic differentiation, in addition to regulating nutrient-associated insulin sensitivity in the intestinal tract. Rodents secrete all four RELM family members, whereas Resistin and RELM-beta are the only RELM family members found in humans.
Predicted MW:Â Dimer, 9.4 / 18.9 kDa (89 / 178 aa)
Resistin-like molecule-gamma (RELM-gamma ) is a member of the RELM family of secreted proteins containing C-terminal cysteines. The RELM family consists of Resistin (FIZZ3), RELM-alpha (FIZZ1), RELM-beta (FIZZ2), and RELM-gamma (FIZZ4). RELM-gamma is secreted by peripheral blood granulocytes, bone marrow, spleen, intestine, and lung. RELM-gamma functions to promote and regulate promyelocytic differentiation, in addition to regulating nutrient-associated insulin sensitivity in the intestinal tract. Rodents secrete all four RELM family members, whereas Resistin and RELM-beta are the only RELM family members found in humans.
Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.  Â
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Secreted |
| Tissue Specificity: | Expressed in colon, lung, spleen, pancreas, ileum and bone marrow (at protein level) (PubMed:15834545). In colon, found throughout the crypt and surface epithelium, including goblet cells (at protein level) (PubMed:15834545). Highest expression is observed in bone marrow, spleen and lung, with lower levels in other tissues (PubMed:12782128, PubMed:14733912, PubMed:15064728, PubMed:15834545). Detected at low levels in granulocytes, but not found in monocytes or lymphocytes (PubMed:14733912). Has very weak expression in white adipose tissue (PubMed:12782128). |
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