Mouse RELM-beta
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| Amount : | 100 µg |
| Purification : | Reducing and Non-Reducing SDS PAGE at >= 95% |
| Content : | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA) Sterile water at 0.1 mg/mL |
| Storage condition : | Store at -20°C |
| AA sequence : | MQCSFESLVD QRIKEALSRQ EPKTISCTSV TSSGRLASCP AGMVVTGCAC GYGCGSWDIR NGNTCHCQCS VMDWASARCC RMA |
Source: Genetically modified E.coli.
Predicted MW:Â Monomer, 8.9 kDa (83 aa)
Resistin-like molecule-beta (RELM-beta ) is a member of the RELM family of secreted proteins containing conserved C-terminus cysteines. The RELM family consists of Resistin (FIZZ3), RELM-alpha (FIZZ1), RELM-beta (FIZZ2), and RELM-gamma (FIZZ4). Resistin and RELM-beta are the only RELM family members found in humans, whereas all four RELM family members are present in rodents. RELM-beta functions to increase fibroblast proliferation and differentiation, resulting in airway remodelling and increased inflammation.
Predicted MW:Â Monomer, 8.9 kDa (83 aa)
Resistin-like molecule-beta (RELM-beta ) is a member of the RELM family of secreted proteins containing conserved C-terminus cysteines. The RELM family consists of Resistin (FIZZ3), RELM-alpha (FIZZ1), RELM-beta (FIZZ2), and RELM-gamma (FIZZ4). Resistin and RELM-beta are the only RELM family members found in humans, whereas all four RELM family members are present in rodents. RELM-beta functions to increase fibroblast proliferation and differentiation, resulting in airway remodelling and increased inflammation.
Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.  Â
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Secreted |
| Tissue Specificity: | Strongly expressed in colon, and at lower levels in ileum (PubMed:15834545). In colon, found throughout the crypt and surface epithelium and in goblet cells (at protein level) (PubMed:15834545). Specific to the gastrointestinal tract; not detected in other tissues tested (PubMed:11209052, PubMed:15834545). |
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