Mouse Monoclonal Antibody to PAX6 (Clone: 193CT15.2.2)(Discontinued)
Figure 1: Western blot analysis of PAX6 Antibody (10-6546) in 293 cell line lysates (35μg/lane). This demonstrates the PAX6 antibody detected the PAX6 protein.
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| Format : | Purified |
| Amount : | 400 µl |
| Isotype : | Mouse IgM,Kappa |
| Content : | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
| Storage condition : | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term store at -20°C in small aliquots to prevent freeze-thaw cycles. |
This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding either the same or different isoform have been found for this gene.
WB~1:100~1000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus |
| Post transnational modification: | Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation. |
| Tissue Specificity: | Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form. |
| BioGrid: | 111114. 48 interactions. |
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