Mouse Monoclonal Antibody to p63a(Clone :BS63)(Discontinued)

Product code: 10-12540

Clone name : BS63
Clonality : Monoclonal
Application : IHC
Reactivity : Human

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Amount : 0.5 ml
Isotype : Mouse IgG1
Content : TRIS with 0.03% sodium azide, pH7.2
Storage condition : Store at 4°C
Gene : TP63
Gene ID : 8626
Uniprot ID : Q9H3D4
Alternative Name : Chronic ulcerative stomatitis protein, Keratinocyte transcription factor KET, Transformation-related protein 63, Tumor protein p73-like, p40, p51, KET, P63, P73H, P73L, TP73L

The p63 gene is a homologue of the p53 tumor suppressor gene. Like p53, p63 contains a transactivation (TA) domain induce the transcription of target genes, a DNA binding domain, and an oligomerization domain (OD), used to form tetramers. In contrast to p53, the p63 gene encodes for at least six major isotypes. Three isotypes (TAp63α, TAp63β, and TAp63γ) contain the transactivating (TA) domain and are able to transactivate p53 report genes and induce apoptosis. In contrast, the other three isotypes (ΔNp63α, ΔNp63β, ΔNp63γ) are transcribed from an internal promoter localized within intron3, lack the TA domain, and act as dominant-negatives to suppress transactivation by both p53 and TAp63 isotypes. p63 is highly expressed in the basal cells of the epithelium significant for proper limb outgrowth and morphogenesis. In differentiating tissues, p63 is crucial for maintaining the stem cell identity of the basal cells, and is indispensable for correct development of the skin as well as the limb. p63-deficient mice lack all squamous epithelia and their derivatives, including hair, whiskers, teeth, as well as mammary, lacrimal, and salivary glands.Tissue specificity: Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.

Immunohistochemical Analysis :-1:250

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Nucleus
Post transnational modification: Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.
Tissue Specificity: Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.
BioGrid: 114181. 129 interactions.
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