Mouse Monoclonal Antibody to MMP14 (C-term)(Clone: 133CT15.10.5.1)(Discontinued)
Figure 1: Anti-MMP14 Antibody (10-6530) at 1:1000 dilution + HT-1080 whole cell lysates/proteins at 20 μg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 66 kDa.
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| Format : | Purified |
| Amount : | 400 µl |
| Isotype : | Mouse IgM |
| Content : | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
| Storage condition : | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
WB~1:100~1000|| IF~1:10~50
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Membrane, Melanosome, Cytoplasm |
| Post transnational modification: | Tyrosine phosphorylated by PKDCC/VLK. |
| Tissue Specificity: | Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. |
| BioGrid: | 110466. 17 interactions. |
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