Mouse Monoclonal Antibody to MLH1(Clone :BS29)

Figure-1: Normal tonsil (Figure-1, Figure-2) and normal appendix (Figure-3) have stained with MLH1 (Clone: BS29) antibody using 1:250 dilution and pH9 tris-EDTA pretreatment. Germinal center cells as well as enterocytes have strong cytoplasmic label. Moderate label observed from cells of the mantle zone.

Mouse Monoclonal Antibody to MLH1(Clone :BS29)

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Figure-1: Normal tonsil (Figure-1, Figure-2) and normal appendix (Figure-3) have stained with MLH1 (Clone: BS29) antibody using 1:250 dilution and pH9 tris-EDTA pretreatment. Germinal center cells as well as enterocytes have strong cytoplasmic label. Moderate label observed from cells of the mantle zone.

Figure-2: Normal tonsil (Figure-1, Figure-2) and normal appendix (Figure-3) have stained with MLH1 (Clone: BS29) antibody using 1:250 dilution and pH9 tris-EDTA pretreatment. Germinal center cells as well as enterocytes have strong cytoplasmic label. Moderate label observed from cells of the mantle zone.

Figure-3: Normal tonsil (Figure-1, Figure-2) and normal appendix (Figure-3) have stained with MLH1 (Clone: BS29) antibody using 1:250 dilution and pH9 tris-EDTA pretreatment. Germinal center cells as well as enterocytes have strong cytoplasmic label. Moderate label observed from cells of the mantle zone.

Product code: 10-12527

Clone name :	BS29
Clonality :	Monoclonal
Application :	IHC
Reactivity :	Human

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For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Amount :	0.5 ml
Isotype :	Mouse IgG1
Content :	TRIS with 0.03% sodium azide, pH7.2
Storage condition :	Store at 4°C


Gene :	MLH1
Gene ID :	4292
Uniprot ID :	P40692
Alternative Name :	MutL protein homolog 1, COCA2

DNA-mismatch repair (MMR), a conserved process that involves correcting errors made during DNA synthesis, is crucial to the maintenance of genomic integrity. Lack of a functional DNA-mismatch repair pathway is a common characteristic of several different types of human cancers, either due to an MMR gene mutation or promoter-methylation gene silencing. MLH1 is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in hereditary nonpolyposis colon cancer (HNPCC). MLH1 is an integral part of the protein complex responsible for mismatch repair expressed in lymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid and gall bladder, and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectal cancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Inactivation of the MLH1 gene causes genome instability and predisposition to cancer. MLH1 also plays a role in meiotic recombination.

Immunohistochemical Analysis :-1:250

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Nucleus, Chromosome
Tissue Specificity:	Colon, lymphocytes, breast, lung, spleen, testis, prostate, thyroid, gall bladder and heart.
BioGrid:	110438. 158 interactions.