Mouse Monoclonal Antibody to Mast Cell Tryptase(Clone: AA1)(Discontinued)

Product code: 10-11566

Clone name : AA1
Clonality : Monoclonal
Application : IHC

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Format : Purified
Amount : 0.5 ml
Isotype : Mouse IgG1
Content : This antibody is supplied as purified immunoglobulin fraction containing sodium azide as preservative.
Storage condition : Store at 2-8°C.
Gene : TPSAB1
Gene ID : 7177
Uniprot ID : Q15661
Alternative Name : Tryptase I, Tryptase alpha-1, TPS1, TPS2, TPSB1
Immunogen Information : BALB/C mice were injected with a purified human lung tryptase.

This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Mast cells contain a number of preformed chemicals mediators such as histamine, chymase, carboxypeptidase, and proteolytic tryptase. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation.

IHC : 1:300-1:600

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Secreted
Tissue Specificity: Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin; in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level).
BioGrid: 113029. 2 interactions.
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