Mouse Monoclonal Antibody to MAPK3 (Clone: 327CT18.1.2)(Discontinued)
Figure 1: Western blot analysis of MAPK3 Antibody (10-6561) in MDA-MB435 cell line lysates (35μg/lane). This demonstrates the MAPK3 antibody detected the MAPK3 protein.
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| Format : | Purified |
| Amount : | 400 µl |
| Isotype : | Mouse IgG1,Kappa |
| Purification : | Protein G Chromatography |
| Content : | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| Storage condition : | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Gene : | MAPK3 |
| Gene ID : | 5595 |
| Uniprot ID : | P27361 |
| Alternative Name : | Mitogen-activated protein kinase 3, MAP kinase 3, MAPK 3, ERT2, Extracellular signal-regulated kinase 1, ERK-1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, p44-MAPK, Microtubule-associated protein 2 kinase, p44-ERK1, MAPK3, ERK1, PRKM3 |
| Immunogen Information : | Recombinant Protein |
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular
signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation,
differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by
upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
WB~1:120~1000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Nucleus, Membrane |
| Post transnational modification: | Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-204. |
| BioGrid: | 111581. 202 interactions. |
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