Mouse Monoclonal Antibody to Human TIM-3 (Clone : TI.B2) (Discontinued)

Product code: 45-1079

Clone name : TI.B2
Clonality : Monoclonal
Application : ELISA

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Format : Purified
Amount : 40 µg
Isotype : Mouse IgG1, Kappa
Purification : Protein A chromatography
Content : 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide.
Storage condition : The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.
Gene : HAVCR2
Gene ID : 84868
Uniprot ID : Q8TDQ0
Alternative Name : T-Cell Immunoglobulin Mucin Receptor 3/HAVCR2/ CD366/ KIM-3/ TIMD3/ Tim-3/ TIMD-3/ HAVcr-2
Immunogen Information : Recombinant human TIM3-Fc

TIM-3 (T cell immunoglobulin and mucin domain-3), is a member of the TIM family of immune regulating molecules. Its binding to Galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. Anti-Human TIM3 Antibody (TI.B2), mAb, Mouse is produced from the hybridoma resulting from fusion of SP2/0 myeloma and B-lymphocytes obtained from mouse immunized with recombinant human TIM3-Fc.

ELISA detection: 0.01-0.1 µg/ml
Flow cytometry: 5-7 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Membrane, Cell junction
Post transnational modification: Phosphorylated on tyrosine residues; modestly increased after TCR/CD28 stimulation. Can be phosphorylated in the cytoplasmatic domain by FYN (By similarity). Phosphorylation at Tyr-265 is increased by stimulation with ligand LGALS9.
Tissue Specificity: Expressed in T-helper type 1 (Th1) lymphocytes. Expressed on regulatory T (Treg) cells after TCR stimulation. Expressed in dendritic cells and natural killer (NK) cells. Expressed in epithelial tissues. Expression is increased on CD4+ and CD8+ T-cells in chronic hepatitis C virus (HCV) infection. In progressive HIV-1 infection, expression is up-regulated on HIV-1-specific CD8 T-cells.
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