Mouse Monoclonal Antibody to Human OX40 (Clone : OX.E12) (Discontinued)
Figure-1 : ELISA binding of OX40 Antibody (Clone: OX.E12) with Human OX40 recombinant protein, Coating antigen: OX40-His at 0.5 µg/ml, Human OX40 Antibody (Clone: OX.E12) dilution start from 1000 ng/ml, EC50= 6.538 ng/ml
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| Format : | Purified |
| Amount : | 40 µg |
| Isotype : | Mouse IgG1,Kappa |
| Purification : | Protein A chromatography |
| Content : | 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide. |
| Storage condition : | The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles. |
| Immunogen Information : | Recombinant human OX40-His |
OX40 (CD134; TNFRSF4) is a T cell co-stimulatory molecule of the TNF receptor superfamily that coordinates with other co-stimulators (CD28, CD40, CD30, CD27 and 4-1BB) to manage the activation of the immune response. OX40 is up-regulated on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. OX40 Ligand is primarily expressed on antigen presenting cells. OX40 Ligand engagement of OX40 on activated CD4+ T cells results in increased T cell survival, proliferation, and cytokine production. It also inhibits the conversion of effector T cells into immunosuppressive regulatory T cells (Tregs) and can promote the maintenance of and recall response in memory T cells. OX40 is constitutively expressed on Tregs and enhances the sensitivity of Tregs to IL-2, thus promoting Treg proliferation. OX40 has also been shown to decrease the cellsÂ’ immunosuppressive activity on effector T cells. OX40-OX40 Ligand signaling is involved in allergic airway inflammation, graft-versus-host disease and autoimmune disease. Mutations in OX40 and OX40 Ligand are associated with cardiovascular disease. Human OX40 Antibody (OX.E12), mAb, Mouse is produced from a hybridoma resulting from the fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with recombinant human OX40-His.
ELISA detection: 0.01-0.1 µg/ml
ELISA blocking: 10-50 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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