Mouse Monoclonal Antibody to Human CTLA-4 (Clone : CT.F3) (Discontinued)

Product code: 45-1077

Clone name : CT.F3
Clonality : Monoclonal
Application : ELISA

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Format : Purified
Amount : 40 µg
Isotype : Mouse IgG1, Kappa
Purification : Protein A chromatography
Content : 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide.
Storage condition : The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.
Gene : CTLA4
Gene ID : 1493
Uniprot ID : P16410
Alternative Name : cytotoxic T-lymphocyte associated protein 4/CD/ GSE/ GRD4/ ALPS5/ CD152/ CTLA-4/ IDDM12/ CELIAC3
Immunogen Information : Recombinant human CTLA4-Fc

CTLA-4 (cytotoxic T-lymphocyte-4, designated CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. CTLA-4 is recruited from intracellular vesicles to the immunological synapse beginning 1-2 days after T cell activation. It forms a linear lattice with B7-1 on APC, inducing negative regulatory signals and ending T cell activation.

ELISA detection: 0.01-0.1 µg/ml
ELISA blocking: 10-15 µg/ml
Flow cytometry: 5-7 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane
Post transnational modification: Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.
Tissue Specificity: Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.
BioGrid: 107875. 109 interactions.
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