Mouse Monoclonal Antibody to Human CD38 (Clone : 38.F2) (Discontinued)
Figure-1 : ELISA binding of CD38 antibody (Clone: 38.F2) with Human CD38 recombinant protein, Coating antigen: Human CD38 recombinant protein at 1 µg/ml, CD38 antibody dilution start from 1000 ng/ml, EC50= 1.268 ng/ml.
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| Format : | Purified |
| Amount : | 40 µg |
| Isotype : | Mouse IgG1,Kappa |
| Purification : | Protein A chromatography |
| Content : | 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide. |
| Storage condition : | The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles. |
| Gene : | CD38 |
| Gene ID : | 952 |
| Uniprot ID : | P28907 |
| Alternative Name : | 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase cyclic ADP-ribose hydrolase,cyclic ADP-ribose hydrolase ADPRC cADPr hydrolase CD38, CD38 antigen (p45), CD38 antigen p45, cluster of differentiation 38, Cyclic ADP-ribose hydrolase cyclic ADP-ribose hydrolase 5, ecto-nicotinamide adenine dinucleotide glycohydrolase, NAD(+) nucleosidase, NAD+ nucleosidase, T10 |
| Immunogen Information : | Recombinant human CD38 |
CD38 glycoprotein is a particularly attractive target on malignant plasma cells at all stages of disease and in Chronic lymphocytic leukemia (also called CLL) patients with a poor clinical prognosis. It is highly expressed in lymphoid tumors including multiple myeloma, AIDS-associated lymphomas, and post-transplant lymphoproliferation. In contrast, the molecule is detectable only at very low levels in mature lymphocytes or in nonhematopoietic tissues. Therputic Anti-CD38 antibodies (e.g. Daratumumab) can induce strong antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity to kill tumors. Anti-Human CD38 Antibody (38.F2), mAb, Mouse is produced from a hybridoma resulting from the fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with recombinant human CD38.
ELISA detection: 0.01-0.1 µg/ml
Flow cytometry: 5 -7 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Membrane |
| Tissue Specificity: | Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. |
| BioGrid: | 107390. 6 interactions. |
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