Mouse Monoclonal Antibody to Histone H3 (Clone: 809CT10.4.2)(Discontinued)
Figure 1: All lanes : Anti-Histone H3 Antibody (10-6619) at 1:2000 dilution with Lane 1: A431 whole cell lysate, Lane 2: C2C12 whole cell lysate, Lane 3: C6 whole cell lysate, Lane 4: Hela whole cell lysate, Lane 5: MCF-7 whole cell lysate, Lane 6: SK-BR-3 whole cell lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 15 kDa.
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| Format : | Purified |
| Amount : | 400 µl |
| Isotype : | Mouse IgG1 |
| Purification : | Protein G Chromatography |
| Content : | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| Storage condition : | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Gene : | HIST1H3A |
| Gene ID : | 8350;8351;8352;8353;8354;8355;8356;8357;8358;8968 |
| Uniprot ID : | P68431 |
| Alternative Name : | Histone H31, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l, HIST1H3A, H3FA |
| Immunogen Information : | Recombinant Protein |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
WB~1:2000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Chromosome |
| Post transnational modification: | Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:30257210). Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac) (PubMed:30257210). |
| BioGrid: | 114458. 10 interactions. |
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