Mouse Monoclonal Antibody to Epidermal Growth Factor(Clone: 111.6)(Discontinued)
Figure 1 : Formalin fixed paraffin embedded human placenta stained with EGFR antibody ( 10-11558).
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| Format : | Purified |
| Amount : | 0.5 ml |
| Isotype : | Mouse IgG1 |
| Content : | This antibody is supplied as purified immunoglobulin fraction containing sodium azide as preservative. |
| Storage condition : | Store at 2-8°C. |
This antibody is specific to a 170 kDa protein. EGF-Receptor is a member of the type I family of growth factor receptors. The antibody recognizes an epitope mapping in the extracellular domain of EGFR. Overexpression of EGFR has been reported in tumors of breast, brain, bladder, lung, stomach, head and neck, esophagus, cervix, vulva, ovary and endometrium. EGFR is over expressed in squamous cell carcinoma.
IHC : 1:25-1:50
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Secreted |
| Post transnational modification: | Methylated. Methylation at Arg-1199 by PRMT5 stimulates phosphorylation at Tyr-1197. |
| Tissue Specificity: | Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers. |
| BioGrid: | 108276. 1217 interactions. |
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