Mouse Monoclonal Antibody to Endoglin (CD105)(Clone :BS71)
Figure-1: CD105/endoglin stained tissue sections. Image (Figure-1) tonsil, (Figure-2) urinary bladder carcinoma and (Figure-3) ductal breast carcinoma sections have been stained using CD105/endoglin antibody (Clone: BS71) with 1:200 dilution. Excellent signal to noise ratio in vascular endothelia of tumor sections.
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| Amount : | 0.5 ml |
| Isotype : | Mouse IgG1 |
| Content : | TRIS with 0.03% sodium azide, pH7.2 |
| Storage condition : | Store at 4°C |
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia.
Immunohistochemical Analysis :-1:200
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane |
| Tissue Specificity: | Detected on blood vessels (at protein level) (PubMed:8194490). Detected on adult pulmonary artery, capillaries supporting the heart muscle and lung alveolar capillary endothelial cells (PubMed:10625534). Endoglin is restricted to endothelial cells in all tissues except bone marrow and is also found in stromal cells within the connective tissue of intestine, stomach, heart, skeletal muscle, uterus, ovary, oviduct, testis and thymus (PubMed:8194490). |
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