Mouse Monoclonal Antibody to E-Cadherin(Clone : DBM15.49)(Discontinued)

Product code: 10-11542

Clone name : DBM15.49
Clonality : Monoclonal
Application : IHC
Reactivity : Human

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Format : Purified
Amount : 0.5 ml
Isotype : Mouse IgG, kappa
Content : This product is supplied as a purified immunoglobulin and contains sodium azide as a preservative.
Storage condition : Store at 2-8°C.
Gene : CDH1
Gene ID : 999
Uniprot ID : P12830
Immunogen Information : Recombinant human E-Cadherin protein.

This antibody recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as β-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.

IHC : 1:50-1:100

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell junction, Cell membrane, Endosome, Golgi apparatus
Post transnational modification: O-glycosylated. O-manosylated by TMTC1, TMTC2, TMTC3 or TMTC4. Thr-285 and Thr-509 are O-mannosylated by TMTC2 or TMTC4 but not TMTC1 or TMTC3.
Tissue Specificity: Non-neural epithelial tissues.
BioGrid: 107434. 631 interactions.
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